Environmental and clinical context in meningococcemia: biochemical modification of stiehm-damrosch/niklasson severity score - prognostic factor

Carmen Manciuc1,2,3, Georgiana Alexandra Lacatusu2,3, Ioana Florina Mihai1,2,3, Cristina Vasilescu2,3, Alexandra Largu1, Florin Petrariu1

1 Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania, Faculty of Medicine, 16 Universita.ii Street, 700115, Ia.i, Rom nia
2 Sf. Parascheva Clinical Hospital of Infectious Diseases Iasi, 2 Octav Botez Street, 700116, Iasi, Romania
3 Sf. Parascheva Clinical Hospital of Infectious Diseases Iasi, 2 Octav Botez Street, 700116, Iasi, Romania

Abstract


The study considers meningococcemia which is one of the most severe form of meningococcal disease and represents a significant worldwide health problem. The occurrence of meningococcemia was investigated based on a case study developed in a Romanian hospital using data taken from the medical records of patients with the diagnosis of meningococcemia. The pathogen can produce a fulminant form of the disease that can lead to death within a few hours of onset. The signs and symptoms of meningococcemia can include an early upper respiratory tract infection with coryza, pharyngitis, tonsillitis, and/or laryngitis which can rapidly be followed by a collapse of the immune system and can ultimately cause multisystem organ failure. We considered the Stiehm-Damrosch/ Niklasson severity score a useful instrument which includes biochemical and clinical factors. Regarding the biochemical factors of the score, the absence of leukocytes in cerebrospinal fluid together with the low level of glucose can be considered important predictors of a severe prognosis.

Keywords


environmental factors; Neisseria meningitidis; pediatric pathology; seasonal occurrence; severity score

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