Effects of carbendazim on dna damage and retrotransposon polymorphism in zea mays

Nalan Yildirim1, Serap Sunar2, Guleray Agar3

1 Department of Biology, Faculty of Science, Erzincan Binali Yildirim University, 24100 Erzincan, Turkey
2 Department of Pharmaceutical Botany, Faculty of Pharmacy, Erzincan Binali Yildirim University, 24000, Erzincan, Turkey
3 Department of Biology, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey


Carbendazim (CBZ, methyl 2-benzimidazolecarbamate) is used widely in agriculture against fungal diseases. We aimed to determine the effects of CBZ (0, 0.1, 0.2 and 0.4 mM) on long terminal repeat (LTR) retrotransposon polymorphism and genomic template stability (GTS), DNA damage using inter-simple sequence repeats (ISSR) and inter-retrotransposon amplified polymorphisms (IRAP) marker techniques. Our results showed that all doses of CBZ compose retrotransposition polymorphism. In additional, our result showed that all CBZ treatment decrease genomic template stability (GTS) and DNA damage increased. These results suggest that carbendazim, widely used in agriculture, can influence unfavorable growth and development of both target and non-target organisms and impend risk to organisms even in trace levels.


carbendazim; DNA damage; genomic template instability; IRAP; ISSR

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