The radioprotective effect of deuterium depleted water and polyphenols

Gabriel C. Corneanu1, Mihaela Corneanu2, Constantin Craciun3, Marin Zagnat4, Ioan Stefanescu5, Marin Popa6

1 Vasile Goldis West University Arad, Biology Department, 92-94 Revolutiei Blvd., Arad, Romania
2 USAMVB Timisoara, Genetics Engineering Department, Timisoara, Romania
3 Babes-Bolyai University, Electron Microscope Center, Cluj-Napoca, Romania
4 UMF Gr.T. Popa, Biotechnology and Protein Technology Department, Iasi, Romania
5 N.R.-D.I. of Cryogenics and Isotopes Separation, R mnicu V lcea, Romania
6 SC Electroputere S.A., Defectoscopy Department, Craiova, Romania


In the experiments performed in mouse (Mus musculus) the radioprotective effect of Deuterium Depleted Water (DDW, with 30 ppm deuterium) and a 0.01% total extract of polyphenols (from Aralia mandshurica cortex) ), applied individually or together was tested, towards a sublethal dose of X-rays (5.28 Gy). The animals were intraperitoneal injected (five injections with 0.5 mL each, one at two days), with single DDW, or with a 0.01% polyphenols diluted in DDW. The stress factor was applied one day after the third injection. As radiobiological point the ultrastructural features of the liver was used (following the animal sacrifice a day after the last injection). The X-irradiation of the animals treated independently or combined with DDW and polyphenols extract, manifest a radioprotective effect, especially in the combined action of the two factors. Also, it was established that the application of a single exogenous factors, enhanced the lipid drops from hepatocyte.


Aralia mandshurica; DDW; liver ultrastructure; polyphenols; radioprotection

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